Enables molecular adaptor activity. Involved in several processes, including positive regulation of interleukin-18-mediated signaling pathway; regulation of cytokine production; and regulation of innate immune response. Located in endoplasmic reticulum; endosome; and phagocytic cup. Is active in endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TICAM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TICAM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TICAM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:113,606,227–113,606,835 | 1995.5 kb | Distal (>10kb) Multiome HiCAR | 306 | |
| chr5:115,295,823–115,297,287 | 305.6 kb | Distal (>10kb) Multiome HiCAR | 763 | |
| chr5:115,384,667–115,385,510 | 217.0 kb | Distal (>10kb) Multiome | 108 | |
| chr5:115,543,835–115,545,478 | 57.4 kb | Distal (>10kb) Multiome | 943 | |
| chr5:115,601,724–115,602,813 | 51 bp | At TSS Multiome | 542 | |
| chr5:115,602,916–115,603,332 | 727 bp | At TSS | 57 | |
| chr5:115,625,502–115,626,687 | 24.0 kb | Distal (>10kb) Multiome | 976 | |
| chr5:115,815,539–115,817,207 | 214.5 kb | Distal (>10kb) Multiome | 490 | |
| chr5:115,840,887–115,842,729 | 239.7 kb | Distal (>10kb) Multiome | 1077 |
Genomic view of the TICAM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.