Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for THNSL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THNSL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THNSL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:24,722,510–24,725,350 | 291.8 kb | Distal (>10kb) Multiome HiCAR | 867 | |
| chr10:24,935,269–24,936,133 | 80.9 kb | Distal (>10kb) Multiome | 154 | |
| chr10:24,947,426–24,948,690 | 68.6 kb | Distal (>10kb) Multiome | 228 | |
| chr10:24,951,142–24,953,416 | 63.6 kb | Distal (>10kb) Multiome | 675 | |
| chr10:25,015,855–25,017,580 | 47 bp | At TSS Multiome | 1101 | |
| chr10:25,174,355–25,177,331 | 158.2 kb | Distal (>10kb) Multiome | 843 |
Genomic view of the THNSL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.