THBS3

thrombospondin 3

The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

Developmental clusters: GC7

Biological processes 14 terms

calcium ion binding (GO:0005509)calcium ion binding (GO:0005509)cell adhesion (GO:0007155)cell-matrix adhesion (GO:0007160)extracellular matrix (GO:0031012)extracellular matrix (GO:0031012)extracellular matrix structural constituent (GO:0005201)extracellular region (GO:0005576)extracellular region (GO:0005576)heparin binding (GO:0008201)heparin binding (GO:0008201)perinuclear region of cytoplasm (GO:0048471)protein binding (GO:0005515)thrombospondin complex (GO:1990341)

Expression (TPM)

TFs regulating THBS3 0 TFs

Transcription factors with Perturb-seq knockdown data for THBS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THBS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to THBS3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THBS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:154,936,148–154,937,752	259.5 kb	Distal (>10kb) Multiome	1149
chr1:154,955,571–154,956,925	240.2 kb	Distal (>10kb) Multiome	504
chr1:154,961,269–154,962,529	234.7 kb	Distal (>10kb) Multiome	985
chr1:154,970,161–154,971,641	225.5 kb	Distal (>10kb) Multiome	535
chr1:154,972,362–154,975,914	221.9 kb	Distal (>10kb) Multiome	1085
chr1:154,982,968–154,983,632	213.2 kb	Distal (>10kb) Multiome	693
chr1:154,998,961–155,004,423	197.1 kb	Distal (>10kb) Multiome	1210
chr1:155,017,084–155,017,941	178.9 kb	Distal (>10kb) Multiome	1003
chr1:155,050,292–155,052,078	145.2 kb	Distal (>10kb) Multiome	948
chr1:155,061,415–155,064,552	132.5 kb	Distal (>10kb) Multiome	860
chr1:155,070,748–155,071,423	125.3 kb	Distal (>10kb) Multiome	542
chr1:155,078,524–155,079,535	117.6 kb	Distal (>10kb) Multiome	397
chr1:155,079,852–155,081,529	115.5 kb	Distal (>10kb) Multiome	539
chr1:155,084,373–155,086,501	111.4 kb	Distal (>10kb) Multiome	865
chr1:155,091,315–155,091,900	104.9 kb	Distal (>10kb) Multiome	594
chr1:155,126,247–155,126,903	70.0 kb	Distal (>10kb) Multiome	776
chr1:155,127,607–155,128,120	68.6 kb	Distal (>10kb) Multiome	578
chr1:155,135,100–155,136,750	60.6 kb	Distal (>10kb) Multiome	938
chr1:155,166,847–155,168,170	28.6 kb	Distal (>10kb) Multiome	622
chr1:155,172,629–155,174,979	23.1 kb	Distal (>10kb) Multiome	903
chr1:155,192,921–155,194,099	2.9 kb	Proximal (<10kb) Multiome	755
chr1:155,194,230–155,195,403	1.6 kb	Proximal (<10kb) Multiome	753
chr1:155,206,922–155,207,633	263 bp	At TSS	431
chr1:155,207,822–155,209,789	12.5 kb	Distal (>10kb) Multiome	826
chr1:155,226,522–155,227,197	30.1 kb	Distal (>10kb) Multiome	600
chr1:155,227,312–155,228,116	31.2 kb	Distal (>10kb) Multiome	688
chr1:155,244,103–155,245,349	48.3 kb	Distal (>10kb) Multiome	900
chr1:155,250,356–155,251,199	54.4 kb	Distal (>10kb) Multiome	605
chr1:155,255,032–155,255,921	59.1 kb	Distal (>10kb) Multiome	661
chr1:155,261,679–155,262,788	65.9 kb	Distal (>10kb) Multiome	921
chr1:155,272,928–155,274,098	77.1 kb	Distal (>10kb) Multiome	768
chr1:155,276,933–155,278,884	82.1 kb	Distal (>10kb) Multiome	749
chr1:155,308,291–155,309,348	112.3 kb	Distal (>10kb) Multiome	934
chr1:155,320,564–155,321,470	124.5 kb	Distal (>10kb) Multiome	341
chr1:155,322,680–155,325,643	127.9 kb	Distal (>10kb) Multiome	979

Genome Browser

Genomic view of the THBS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.