Transcription factors with Perturb-seq knockdown data for TGFB2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TGFB2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TGFB2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:218,336,121–218,336,860 | 9.0 kb | Proximal (<10kb) | 193 | |
| chr1:218,339,379–218,339,746 | 6.1 kb | Proximal (<10kb) | 99 | |
| chr1:218,341,133–218,341,815 | 4.1 kb | Proximal (<10kb) | 149 | |
| chr1:218,344,881–218,346,381 | at TSS | At TSS | 644 | |
| chr1:218,346,696–218,348,498 | 818 bp | At TSS | 372 | |
| chr1:218,351,629–218,351,845 | 5.8 kb | Proximal (<10kb) | 133 |
Genomic view of the TGFB2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.