This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Transcription factors with Perturb-seq knockdown data for TFIP11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFIP11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFIP11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:26,428,616–26,429,779 | 83.3 kb | Distal (>10kb) Multiome | 481 | |
| chr22:26,483,346–26,484,220 | 28.7 kb | Distal (>10kb) Multiome | 895 | |
| chr22:26,512,193–26,512,760 | 29 bp | At TSS Multiome | 692 | |
| chr22:26,588,940–26,590,564 | 77.7 kb | Distal (>10kb) Multiome | 545 | |
| chr22:26,632,639–26,633,120 | 120.4 kb | Distal (>10kb) Multiome | 225 | |
| chr22:26,644,963–26,645,832 | 133.0 kb | Distal (>10kb) Multiome | 522 | |
| chr22:26,658,631–26,659,207 | 146.5 kb | Distal (>10kb) Multiome HiCAR | 485 | |
| chr22:26,672,265–26,673,339 | 160.4 kb | Distal (>10kb) Multiome | 604 |
Genomic view of the TFIP11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.