transferrin | PRO1557, PRO2086

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Biological processes 55 terms

HFE-transferrin receptor complex (GO:1990712)antibacterial humoral response (GO:0019731)apical plasma membrane (GO:0016324)basal part of cell (GO:0045178)basal plasma membrane (GO:0009925)blood microparticle (GO:0072562)cell surface (GO:0009986)cell surface receptor signaling pathway (GO:0007166)cellular response to iron ion (GO:0071281)clathrin-coated endocytic vesicle membrane (GO:0030669)clathrin-coated pit (GO:0005905)cytoplasmic vesicle (GO:0031410)early endosome (GO:0005769)early endosome (GO:0005769)endocytic vesicle (GO:0030139)endoplasmic reticulum lumen (GO:0005788)endosome membrane (GO:0010008)enzyme binding (GO:0019899)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)ferric iron binding (GO:0008199)ferrous iron binding (GO:0008198)intracellular iron ion homeostasis (GO:0006879)intracellular iron ion homeostasis (GO:0006879)iron chaperone activity (GO:0034986)iron ion binding (GO:0005506)iron ion transport (GO:0006826)iron ion transport (GO:0006826)iron ion transport (GO:0006826)iron ion transport (GO:0006826)late endosome (GO:0005770)membrane (GO:0016020)multicellular organismal-level iron ion homeostasis (GO:0060586)osteoclast differentiation (GO:0030316)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of receptor-mediated endocytosis (GO:0048260)positive regulation of receptor-mediated endocytosis (GO:0048260)protein binding (GO:0005515)recycling endosome (GO:0055037)recycling endosome (GO:0055037)regulation of protein stability (GO:0031647)secretory granule lumen (GO:0034774)transferrin receptor binding (GO:1990459)transferrin receptor binding (GO:1990459)transmembrane transporter binding (GO:0044325)vesicle (GO:0031982)

Expression (TPM)