Located in coated vesicle membrane and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TEPSIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEPSIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEPSIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:80,981,166–80,981,777 | 257.5 kb | Distal (>10kb) Multiome | 249 | |
| chr17:81,033,927–81,036,743 | 204.0 kb | Distal (>10kb) Multiome | 822 | |
| chr17:81,101,596–81,102,059 | 137.2 kb | Distal (>10kb) Multiome | 815 | |
| chr17:81,222,360–81,223,690 | 15.9 kb | Distal (>10kb) Multiome | 861 | |
| chr17:81,238,602–81,239,760 | 137 bp | At TSS Multiome | 811 | |
| chr17:81,241,713–81,241,938 | 2.7 kb | Proximal (<10kb) | 354 | |
| chr17:81,295,024–81,295,658 | 56.3 kb | Distal (>10kb) Multiome | 832 | |
| chr17:81,339,311–81,340,470 | 100.4 kb | Distal (>10kb) Multiome | 474 | |
| chr17:81,345,409–81,347,165 | 107.2 kb | Distal (>10kb) Multiome | 891 | |
| chr17:81,393,141–81,395,575 | 156.3 kb | Distal (>10kb) Multiome | 1168 | |
| chr17:81,396,480–81,397,832 | 158.5 kb | Distal (>10kb) Multiome | 646 | |
| chr17:81,481,258–81,481,865 | 242.5 kb | Distal (>10kb) Multiome | 348 | |
| chr17:81,483,927–81,484,829 | 245.4 kb | Distal (>10kb) Multiome | 828 | |
| chr17:81,487,690–81,488,371 | 249.0 kb | Distal (>10kb) Multiome | 721 | |
| chr17:81,511,887–81,515,656 | 275.9 kb | Distal (>10kb) Multiome | 1116 | |
| chr17:81,537,462–81,537,907 | 298.6 kb | Distal (>10kb) Multiome | 282 |
Genomic view of the TEPSIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.