The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for TENT4A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TENT4A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TENT4A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:6,475,554–6,476,306 | 237.5 kb | Distal (>10kb) Multiome | 93 | |
| chr5:6,582,577–6,583,754 | 130.2 kb | Distal (>10kb) Multiome | 244 | |
| chr5:6,595,290–6,596,038 | 117.8 kb | Distal (>10kb) Multiome | 157 | |
| chr5:6,632,465–6,634,316 | 80.1 kb | Distal (>10kb) Multiome HiCAR | 837 | |
| chr5:6,686,711–6,687,368 | 26.3 kb | Distal (>10kb) Multiome | 390 | |
| chr5:6,712,052–6,714,014 | 216 bp | At TSS Multiome | 953 | |
| chr5:6,714,126–6,714,843 | 695 bp | At TSS | 253 | |
| chr5:6,765,540–6,766,155 | 52.4 kb | Distal (>10kb) Multiome | 329 | |
| chr5:6,818,419–6,819,319 | 105.3 kb | Distal (>10kb) Multiome | 115 | |
| chr5:6,978,618–6,979,848 | 265.8 kb | Distal (>10kb) Multiome | 110 | |
| chr5:7,849,610–7,851,526 | 1137.2 kb | Distal (>10kb) Multiome HiCAR | 471 |
Genomic view of the TENT4A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.