TEN1
TEN1 subunit of CST complex | FLJ39785, C17orf106

C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

Biological processes 18 terms
CST complex (GO:1990879)CST complex (GO:1990879)CST complex (GO:1990879)CST complex (GO:1990879)chromosome, telomeric region (GO:0000781)chromosome, telomeric region (GO:0000781)negative regulation of telomere maintenance via telomerase (GO:0032211)negative regulation of telomere maintenance via telomerase (GO:0032211)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)single-stranded DNA binding (GO:0003697)telomerase inhibitor activity (GO:0010521)telomere capping (GO:0016233)telomeric repeat DNA binding (GO:0042162)telomeric repeat DNA binding (GO:0042162)
Expression (TPM)
TEN1 — as a Regulated Gene

TFs regulating TEN1 0 TFs

Transcription factors with Perturb-seq knockdown data for TEN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TEN1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:75,720,933–75,721,693 257.9 kb Distal (>10kb) Multiome 509
chr17:75,753,534–75,754,285 225.4 kb Distal (>10kb) Multiome 699
chr17:75,764,621–75,765,674 214.1 kb Distal (>10kb) Multiome 769
chr17:75,778,786–75,780,191 199.4 kb Distal (>10kb) Multiome 1118
chr17:75,784,060–75,785,640 194.4 kb Distal (>10kb) Multiome 1176
chr17:75,827,420–75,828,293 151.5 kb Distal (>10kb) Multiome 404
chr17:75,830,158–75,830,695 148.9 kb Distal (>10kb) Multiome 190
chr17:75,832,912–75,833,396 146.1 kb Distal (>10kb) Multiome 104
chr17:75,845,103–75,845,662 133.9 kb Distal (>10kb) Multiome 703
chr17:75,854,955–75,856,363 123.7 kb Distal (>10kb) Multiome 1038
chr17:75,877,486–75,878,900 101.2 kb Distal (>10kb) Multiome 884
chr17:75,896,392–75,897,754 82.3 kb Distal (>10kb) Multiome 831
chr17:75,904,371–75,905,532 74.2 kb Distal (>10kb) Multiome 1045
chr17:75,940,734–75,941,471 38.2 kb Distal (>10kb) Multiome 982
chr17:75,978,646–75,980,102 113 bp At TSS Multiome 1090
chr17:75,983,292–75,984,226 4.6 kb Proximal (<10kb) Multiome 236
chr17:76,014,120–76,014,727 35.1 kb Distal (>10kb) Multiome 489
chr17:76,029,331–76,030,158 50.4 kb Distal (>10kb) Multiome 722
chr17:76,072,173–76,072,853 93.3 kb Distal (>10kb) Multiome 893
chr17:76,074,414–76,075,796 95.4 kb Distal (>10kb) Multiome 280
chr17:76,103,272–76,104,343 124.5 kb Distal (>10kb) Multiome 798
chr17:76,121,142–76,122,265 142.3 kb Distal (>10kb) Multiome 689
chr17:76,132,004–76,133,216 153.5 kb Distal (>10kb) Multiome 536
chr17:76,135,151–76,135,652 156.0 kb Distal (>10kb) Multiome 104
chr17:76,141,012–76,141,958 162.1 kb Distal (>10kb) Multiome 616
chr17:76,240,278–76,241,169 261.4 kb Distal (>10kb) Multiome 560
chr17:76,264,834–76,266,286 285.9 kb Distal (>10kb) Multiome 868

Genome Browser

Genomic view of the TEN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:75,710,933 – 76,276,286
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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