Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in centriole and cilium. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TEDC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEDC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEDC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:2,178,140–2,179,722 | 281.3 kb | Distal (>10kb) Multiome | 318 | |
| chr16:2,205,129–2,206,297 | 254.6 kb | Distal (>10kb) Multiome | 887 | |
| chr16:2,214,212–2,215,803 | 245.1 kb | Distal (>10kb) Multiome | 953 | |
| chr16:2,223,095–2,224,285 | 236.6 kb | Distal (>10kb) Multiome | 918 | |
| chr16:2,251,044–2,252,460 | 208.4 kb | Distal (>10kb) Multiome | 996 | |
| chr16:2,267,625–2,269,111 | 191.8 kb | Distal (>10kb) Multiome HiCAR | 1044 | |
| chr16:2,339,631–2,342,283 | 119.3 kb | Distal (>10kb) Multiome | 1129 | |
| chr16:2,428,282–2,429,948 | 30.8 kb | Distal (>10kb) Multiome | 827 | |
| chr16:2,459,524–2,460,612 | 42 bp | At TSS Multiome | 670 | |
| chr16:2,467,565–2,468,324 | 7.7 kb | Proximal (<10kb) Multiome | 450 | |
| chr16:2,468,439–2,469,135 | 8.3 kb | Proximal (<10kb) | 438 | |
| chr16:2,470,913–2,472,223 | 11.2 kb | Distal (>10kb) Multiome | 427 | |
| chr16:2,473,455–2,476,127 | 15.1 kb | Distal (>10kb) Multiome | 719 | |
| chr16:2,501,124–2,501,877 | 41.3 kb | Distal (>10kb) Multiome | 471 | |
| chr16:2,513,006–2,514,809 | 53.7 kb | Distal (>10kb) Multiome | 818 | |
| chr16:2,520,064–2,520,618 | 60.2 kb | Distal (>10kb) Multiome | 624 | |
| chr16:2,531,456–2,533,080 | 72.0 kb | Distal (>10kb) Multiome | 883 | |
| chr16:2,537,433–2,538,433 | 77.8 kb | Distal (>10kb) Multiome | 498 | |
| chr16:2,603,176–2,603,939 | 143.3 kb | Distal (>10kb) Multiome | 1066 | |
| chr16:2,673,059–2,673,910 | 213.4 kb | Distal (>10kb) Multiome | 471 | |
| chr16:2,682,205–2,683,006 | 222.4 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:2,720,741–2,721,896 | 261.2 kb | Distal (>10kb) Multiome | 758 | |
| chr16:2,751,637–2,753,398 | 292.4 kb | Distal (>10kb) Multiome | 1074 |
Genomic view of the TEDC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.