The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TECTA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TECTA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TECTA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:120,929,398–120,930,110 | 200.2 kb | Distal (>10kb) Multiome | 242 | |
| chr11:120,952,870–120,953,318 | 176.9 kb | Distal (>10kb) Multiome HiCAR | 268 | |
| chr11:120,974,585–120,975,367 | 154.8 kb | Distal (>10kb) Multiome | 102 | |
| chr11:120,985,786–120,986,410 | 143.8 kb | Distal (>10kb) Multiome | 340 | |
| chr11:121,023,770–121,024,643 | 105.9 kb | Distal (>10kb) Multiome | 720 | |
| chr11:121,282,691–121,283,424 | 153.1 kb | Distal (>10kb) Multiome | 96 | |
| chr11:121,292,065–121,293,479 | 162.8 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the TECTA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.