Enables chromatin binding activity; methylated histone binding activity; and transcription coactivator activity. Predicted to be involved in DNA topological change. Located in Golgi apparatus; cytosol; and nucleus. Part of DNA topoisomerase III-beta-TDRD3 complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TDRD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TDRD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TDRD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:60,158,272–60,159,705 | 238.1 kb | Distal (>10kb) Multiome | 237 | |
| chr13:60,163,281–60,164,945 | 233.0 kb | Distal (>10kb) Multiome | 821 | |
| chr13:60,165,156–60,166,059 | 231.4 kb | Distal (>10kb) Multiome | 211 | |
| chr13:60,267,323–60,268,202 | 129.2 kb | Distal (>10kb) Multiome | 201 | |
| chr13:60,331,090–60,331,740 | 65.6 kb | Distal (>10kb) Multiome | 67 | |
| chr13:60,391,994–60,392,471 | 4.5 kb | Proximal (<10kb) | 6 | |
| chr13:60,395,838–60,398,034 | 536 bp | At TSS Multiome | 985 | |
| chr13:60,572,140–60,573,322 | 175.7 kb | Distal (>10kb) Multiome | 357 | |
| chr13:60,583,393–60,585,771 | 187.6 kb | Distal (>10kb) Multiome | 540 |
Genomic view of the TDRD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.