This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for TCTN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCTN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCTN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:123,383,367–123,384,963 | 287.2 kb | Distal (>10kb) Multiome | 836 | |
| chr12:123,388,500–123,389,409 | 282.2 kb | Distal (>10kb) Multiome | 446 | |
| chr12:123,436,072–123,436,895 | 234.5 kb | Distal (>10kb) Multiome | 742 | |
| chr12:123,458,045–123,458,697 | 212.7 kb | Distal (>10kb) Multiome | 925 | |
| chr12:123,533,444–123,534,540 | 137.1 kb | Distal (>10kb) Multiome | 718 | |
| chr12:123,583,890–123,585,003 | 86.6 kb | Distal (>10kb) Multiome | 928 | |
| chr12:123,601,617–123,602,401 | 69.1 kb | Distal (>10kb) Multiome | 1076 | |
| chr12:123,633,273–123,633,970 | 37.3 kb | Distal (>10kb) Multiome | 886 | |
| chr12:123,670,899–123,671,414 | 17 bp | At TSS Multiome | 469 | |
| chr12:123,711,684–123,712,955 | 41.2 kb | Distal (>10kb) Multiome | 771 | |
| chr12:123,719,176–123,720,140 | 48.6 kb | Distal (>10kb) Multiome | 303 | |
| chr12:123,761,832–123,763,058 | 91.0 kb | Distal (>10kb) Multiome | 416 |
Genomic view of the TCTN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.