Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TCEANC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCEANC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCEANC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:53,838,019–53,838,779 | 215.2 kb | Distal (>10kb) Multiome | 1058 | |
| chr1:53,889,527–53,890,054 | 163.8 kb | Distal (>10kb) Multiome | 654 | |
| chr1:53,944,886–53,946,958 | 107.6 kb | Distal (>10kb) Multiome | 806 | |
| chr1:53,956,851–53,957,534 | 96.4 kb | Distal (>10kb) Multiome | 255 | |
| chr1:54,052,651–54,054,132 | 160 bp | At TSS Multiome | 833 | |
| chr1:54,121,133–54,122,207 | 68.0 kb | Distal (>10kb) Multiome | 490 | |
| chr1:54,199,512–54,200,664 | 146.5 kb | Distal (>10kb) Multiome | 741 | |
| chr1:54,800,637–54,801,431 | 747.6 kb | Distal (>10kb) Multiome HiCAR | 286 |
Genomic view of the TCEANC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.