Involved in several processes, including DNA replication; protein localization to nucleoplasm; and protein stabilization. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBRG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBRG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBRG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:124,622,373–124,623,302 | 61 bp | At TSS Multiome | 828 | |
| chr11:124,673,250–124,674,391 | 50.9 kb | Distal (>10kb) Multiome | 715 | |
| chr11:124,739,482–124,740,822 | 117.0 kb | Distal (>10kb) Multiome | 498 | |
| chr11:124,745,504–124,747,699 | 124.1 kb | Distal (>10kb) Multiome | 676 | |
| chr11:124,758,225–124,760,203 | 135.7 kb | Distal (>10kb) Multiome | 594 | |
| chr11:124,799,320–124,800,957 | 177.7 kb | Distal (>10kb) Multiome | 893 | |
| chr11:124,839,093–124,840,110 | 216.9 kb | Distal (>10kb) Multiome | 246 | |
| chr11:124,842,870–124,844,108 | 220.5 kb | Distal (>10kb) Multiome | 219 | |
| chr11:124,875,886–124,877,815 | 253.6 kb | Distal (>10kb) Multiome | 769 | |
| chr11:124,920,725–124,921,671 | 298.3 kb | Distal (>10kb) Multiome | 329 |
Genomic view of the TBRG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.