Enables GTPase activator activity and small GTPase binding activity. Involved in negative regulation of cilium assembly and positive regulation of GTPase activity. Located in several cellular components, including ciliary basal body; cytosol; and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D30. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D30 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D30, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:64,543,521–64,544,182 | 236.8 kb | Distal (>10kb) Multiome | 54 | |
| chr12:64,608,914–64,611,341 | 170.1 kb | Distal (>10kb) Multiome | 922 | |
| chr12:64,681,872–64,683,616 | 97.6 kb | Distal (>10kb) Multiome | 397 | |
| chr12:64,758,714–64,760,174 | 21.1 kb | Distal (>10kb) Multiome | 809 | |
| chr12:64,780,224–64,781,694 | 304 bp | At TSS Multiome | 599 | |
| chr12:64,824,273–64,825,855 | 44.2 kb | Distal (>10kb) Multiome | 351 |
Genomic view of the TBC1D30 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.