Predicted to enable GTPase activator activity. Involved in endocytosis. Located in cytosol and early endosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:77,818,998–77,820,547 | 257.5 kb | Distal (>10kb) Multiome | 353 | |
| chr15:78,077,036–78,077,991 | 138 bp | At TSS Multiome | 552 | |
| chr15:78,130,851–78,132,005 | 53.8 kb | Distal (>10kb) Multiome | 769 | |
| chr15:78,148,893–78,150,142 | 71.6 kb | Distal (>10kb) Multiome | 746 | |
| chr15:78,264,436–78,265,112 | 187.0 kb | Distal (>10kb) Multiome | 241 | |
| chr15:78,299,130–78,299,874 | 221.9 kb | Distal (>10kb) Multiome | 798 | |
| chr15:78,303,744–78,304,214 | 226.2 kb | Distal (>10kb) Multiome | 287 | |
| chr15:78,340,100–78,340,745 | 262.6 kb | Distal (>10kb) Multiome | 194 | |
| chr15:78,348,106–78,348,824 | 270.7 kb | Distal (>10kb) Multiome | 178 |
Genomic view of the TBC1D2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.