This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for TBC1D20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:266,689–267,291 | 195.4 kb | Distal (>10kb) Multiome | 931 | |
| chr20:290,009–290,864 | 172.0 kb | Distal (>10kb) Multiome | 706 | |
| chr20:297,159–298,781 | 165.1 kb | Distal (>10kb) Multiome | 1084 | |
| chr20:300,984–301,434 | 161.2 kb | Distal (>10kb) Multiome | 252 | |
| chr20:309,597–310,812 | 152.0 kb | Distal (>10kb) Multiome | 589 | |
| chr20:323,634–328,069 | 135.3 kb | Distal (>10kb) Multiome | 1260 | |
| chr20:330,299–330,873 | 131.8 kb | Distal (>10kb) Multiome | 376 | |
| chr20:346,592–348,332 | 114.6 kb | Distal (>10kb) Multiome | 1061 | |
| chr20:354,335–354,944 | 107.9 kb | Distal (>10kb) Multiome | 631 | |
| chr20:380,569–381,493 | 81.6 kb | Distal (>10kb) Multiome | 958 | |
| chr20:381,625–382,263 | 80.5 kb | Distal (>10kb) Multiome | 745 | |
| chr20:407,136–409,109 | 54.5 kb | Distal (>10kb) Multiome | 1064 | |
| chr20:461,861–463,102 | 19 bp | At TSS Multiome | 871 | |
| chr20:543,069–544,398 | 81.3 kb | Distal (>10kb) Multiome | 965 | |
| chr20:555,914–556,523 | 93.7 kb | Distal (>10kb) Multiome | 249 | |
| chr20:574,398–574,909 | 112.2 kb | Distal (>10kb) Multiome | 119 | |
| chr20:609,984–610,596 | 147.8 kb | Distal (>10kb) Multiome | 205 | |
| chr20:652,813–653,697 | 190.9 kb | Distal (>10kb) Multiome | 897 | |
| chr20:675,301–676,096 | 213.2 kb | Distal (>10kb) Multiome | 782 | |
| chr20:709,891–710,669 | 247.7 kb | Distal (>10kb) Multiome | 168 | |
| chr20:727,954–728,888 | 266.0 kb | Distal (>10kb) Multiome | 621 |
Genomic view of the TBC1D20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.