Enables PDZ domain binding activity. Involved in positive regulation of proteolysis and retrograde transport, endosome to Golgi. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D10A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D10A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D10A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,079,923–30,080,552 | 246.6 kb | Distal (>10kb) Multiome | 167 | |
| chr22:30,255,880–30,256,357 | 70.8 kb | Distal (>10kb) Multiome | 546 | |
| chr22:30,287,851–30,288,373 | 38.8 kb | Distal (>10kb) Multiome | 423 | |
| chr22:30,288,952–30,290,454 | 37.2 kb | Distal (>10kb) Multiome | 570 | |
| chr22:30,326,296–30,327,463 | 135 bp | At TSS Multiome | 565 | |
| chr22:30,356,495–30,357,510 | 30.0 kb | Distal (>10kb) Multiome | 824 | |
| chr22:30,386,775–30,387,972 | 60.5 kb | Distal (>10kb) Multiome | 499 | |
| chr22:30,392,372–30,393,155 | 65.9 kb | Distal (>10kb) Multiome | 209 | |
| chr22:30,396,849–30,397,353 | 70.1 kb | Distal (>10kb) Multiome | 385 | |
| chr22:30,422,945–30,424,825 | 97.2 kb | Distal (>10kb) Multiome | 1038 | |
| chr22:30,425,449–30,426,228 | 98.8 kb | Distal (>10kb) Multiome | 617 | |
| chr22:30,426,363–30,426,817 | 99.8 kb | Distal (>10kb) Multiome | 374 | |
| chr22:30,574,045–30,575,001 | 247.8 kb | Distal (>10kb) Multiome | 283 | |
| chr22:30,591,677–30,592,568 | 265.2 kb | Distal (>10kb) Multiome | 698 | |
| chr22:30,606,243–30,607,508 | 279.9 kb | Distal (>10kb) Multiome | 507 |
Genomic view of the TBC1D10A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.