This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TAS2R4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAS2R4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAS2R4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:141,511,342–141,512,397 | 264.6 kb | Distal (>10kb) Multiome | 217 | |
| chr7:141,550,725–141,551,853 | 225.3 kb | Distal (>10kb) Multiome | 899 | |
| chr7:141,584,907–141,585,342 | 191.6 kb | Distal (>10kb) Multiome | 149 | |
| chr7:141,701,501–141,702,649 | 74.5 kb | Distal (>10kb) Multiome | 455 | |
| chr7:141,737,828–141,738,838 | 38.4 kb | Distal (>10kb) Multiome | 1117 | |
| chr7:141,776,659–141,776,922 | at TSS | At TSS | 14 | |
| chr7:141,785,849–141,786,226 | 9.2 kb | Proximal (<10kb) | 81 | |
| chr7:141,975,843–141,976,803 | 199.7 kb | Distal (>10kb) Multiome | 357 | |
| chr7:141,994,100–141,994,957 | 217.9 kb | Distal (>10kb) Multiome | 70 |
Genomic view of the TAS2R4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.