Predicted to be involved in protein secretion. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TANGO6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TANGO6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TANGO6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:68,520,489–68,521,019 | 322.8 kb | Distal (>10kb) Multiome HiCAR | 602 | |
| chr16:68,528,418–68,529,128 | 314.9 kb | Distal (>10kb) Multiome HiCAR | 552 | |
| chr16:68,529,733–68,530,671 | 313.4 kb | Distal (>10kb) Multiome HiCAR | 831 | |
| chr16:68,642,503–68,643,044 | 200.9 kb | Distal (>10kb) Multiome | 288 | |
| chr16:68,644,824–68,646,405 | 198.3 kb | Distal (>10kb) Multiome | 442 | |
| chr16:68,736,847–68,738,492 | 106.4 kb | Distal (>10kb) Multiome | 537 | |
| chr16:68,778,480–68,779,271 | 64.6 kb | Distal (>10kb) Multiome | 248 | |
| chr16:68,843,238–68,844,359 | 199 bp | At TSS Multiome | 918 | |
| chr16:68,972,806–68,973,019 | 19 bp | At TSS | 123 | |
| chr16:69,071,809–69,072,879 | 228.7 kb | Distal (>10kb) Multiome | 386 | |
| chr16:69,105,371–69,107,181 | 262.6 kb | Distal (>10kb) Multiome HiCAR | 631 | |
| chr16:69,131,353–69,133,059 | 288.8 kb | Distal (>10kb) Multiome | 961 | |
| chr16:69,170,078–69,170,680 | 326.8 kb | Distal (>10kb) Multiome | 43 | |
| chr16:69,186,569–69,187,845 | 343.5 kb | Distal (>10kb) Multiome | 878 | |
| chr16:69,310,637–69,312,153 | 467.7 kb | Distal (>10kb) Multiome HiCAR | 963 |
Genomic view of the TANGO6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.