This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for TANGO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TANGO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TANGO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:19,717,840–19,718,731 | 298.8 kb | Distal (>10kb) Multiome | 592 | |
| chr22:19,723,413–19,724,584 | 292.8 kb | Distal (>10kb) Multiome | 572 | |
| chr22:19,730,516–19,731,296 | 286.1 kb | Distal (>10kb) Multiome | 743 | |
| chr22:19,765,840–19,766,429 | 250.8 kb | Distal (>10kb) Multiome | 174 | |
| chr22:19,854,381–19,855,705 | 162.1 kb | Distal (>10kb) Multiome | 1014 | |
| chr22:19,891,576–19,892,031 | 125.3 kb | Distal (>10kb) Multiome | 631 | |
| chr22:19,959,058–19,959,828 | 57.5 kb | Distal (>10kb) Multiome | 576 | |
| chr22:19,962,339–19,962,798 | 54.5 kb | Distal (>10kb) Multiome HiCAR | 442 | |
| chr22:19,986,350–19,987,426 | 29.9 kb | Distal (>10kb) Multiome | 539 | |
| chr22:20,013,336–20,013,713 | 3.3 kb | Proximal (<10kb) | 310 | |
| chr22:20,016,068–20,017,437 | 165 bp | At TSS Multiome | 640 | |
| chr22:20,020,662–20,021,745 | 4.0 kb | Proximal (<10kb) Multiome | 718 | |
| chr22:20,079,663–20,080,743 | 63.1 kb | Distal (>10kb) Multiome | 994 | |
| chr22:20,116,628–20,118,048 | 100.3 kb | Distal (>10kb) Multiome | 999 | |
| chr22:20,130,806–20,131,896 | 114.2 kb | Distal (>10kb) Multiome | 525 | |
| chr22:20,203,393–20,204,086 | 186.8 kb | Distal (>10kb) Multiome | 292 | |
| chr22:20,243,636–20,244,300 | 227.0 kb | Distal (>10kb) Multiome | 251 | |
| chr22:20,267,373–20,268,700 | 251.4 kb | Distal (>10kb) Multiome | 449 | |
| chr22:20,298,366–20,300,076 | 282.2 kb | Distal (>10kb) Multiome | 538 | |
| chr22:20,319,527–20,320,815 | 303.1 kb | Distal (>10kb) Multiome | 805 |
Genomic view of the TANGO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.