TAF9B

TATA-box binding protein associated factor 9b | DN-7, DN7, TAFII31L, TFIID-31, TAF9L

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]

Biological processes 21 terms

DNA-templated transcription initiation (GO:0006352)RNA polymerase II general transcription initiation factor activity (GO:0016251)RNA polymerase II general transcription initiation factor activity (GO:0016251)RNA polymerase II general transcription initiation factor activity (GO:0016251)negative regulation of apoptotic process (GO:0043066)negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:1902166)negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:1902166)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)positive regulation of cell growth (GO:0030307)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein stabilization (GO:0050821)transcription by RNA polymerase II (GO:0006366)transcription corepressor activity (GO:0003714)transcription factor TFIID complex (GO:0005669)transcription factor TFIID complex (GO:0005669)transcription factor TFIID complex (GO:0005669)transcription factor TFTC complex (GO:0033276)transcription factor TFTC complex (GO:0033276)

Expression (TPM)

TFs regulating TAF9B 0 TFs

Transcription factors with Perturb-seq knockdown data for TAF9B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAF9B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TAF9B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAF9B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chrX:77,894,933–77,895,826	244.1 kb	Distal (>10kb) Multiome	543
chrX:77,899,137–77,899,809	240.3 kb	Distal (>10kb) Multiome	504
chrX:77,910,405–77,911,140	229.0 kb	Distal (>10kb) Multiome	574
chrX:78,103,641–78,105,079	35.6 kb	Distal (>10kb) Multiome	867
chrX:78,139,006–78,140,056	6 bp	At TSS Multiome	593
chrX:78,213,300–78,214,197	73.9 kb	Distal (>10kb) Multiome	196

Genome Browser

Genomic view of the TAF9B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.