TAF1C

TATA-box binding protein associated factor, RNA polymerase I subunit C | MGC:39976, SL1, TAFI110, TAFI95

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

Biological processes 18 terms

RNA polymerase I core factor complex (GO:0070860)RNA polymerase I core promoter sequence-specific DNA binding (GO:0001164)RNA polymerase I core promoter sequence-specific DNA binding (GO:0001164)RNA polymerase I general transcription initiation factor activity (GO:0001181)RNA polymerase I preinitiation complex assembly (GO:0001188)RNA polymerase transcription factor SL1 complex (GO:0005668)fibrillar center (GO:0001650)fibrillar center (GO:0001650)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)transcription by RNA polymerase I (GO:0006360)transcription by RNA polymerase I (GO:0006360)transcription by RNA polymerase II (GO:0006366)transcription initiation at RNA polymerase I promoter (GO:0006361)

Expression (TPM)

TFs regulating TAF1C 0 TFs

Transcription factors with Perturb-seq knockdown data for TAF1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAF1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TAF1C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAF1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:83,888,352–83,889,387	298.3 kb	Distal (>10kb) Multiome	237
chr16:83,898,559–83,899,828	288.0 kb	Distal (>10kb) Multiome	773
chr16:83,926,399–83,927,376	260.2 kb	Distal (>10kb) Multiome	532
chr16:83,968,110–83,968,725	218.6 kb	Distal (>10kb) Multiome	261
chr16:84,013,600–84,015,009	172.8 kb	Distal (>10kb) Multiome	388
chr16:84,043,411–84,043,885	143.3 kb	Distal (>10kb) Multiome	292
chr16:84,062,518–84,063,095	124.2 kb	Distal (>10kb) Multiome	330
chr16:84,116,331–84,117,716	70.1 kb	Distal (>10kb) Multiome	1013
chr16:84,144,637–84,145,742	41.8 kb	Distal (>10kb) Multiome	679
chr16:84,186,615–84,187,246	9 bp	At TSS Multiome	848
chr16:84,268,108–84,268,844	81.4 kb	Distal (>10kb) Multiome	42
chr16:84,367,919–84,368,944	181.4 kb	Distal (>10kb) Multiome	287

Genome Browser

Genomic view of the TAF1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.