This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for TAF1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAF1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAF1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:222,464,889–222,466,000 | 124.3 kb | Distal (>10kb) Multiome | 1097 | |
| chr1:222,589,519–222,590,254 | 6 bp | At TSS Multiome | 689 | |
| chr1:222,617,261–222,619,333 | 28.0 kb | Distal (>10kb) Multiome | 690 | |
| chr1:222,643,693–222,644,710 | 54.3 kb | Distal (>10kb) Multiome | 917 | |
| chr1:222,711,408–222,713,804 | 122.7 kb | Distal (>10kb) Multiome | 1037 | |
| chr1:222,814,519–222,815,531 | 225.2 kb | Distal (>10kb) Multiome | 704 |
Genomic view of the TAF1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.