This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]
Transcription factors with Perturb-seq knockdown data for TACR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TACR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TACR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:74,919,661–74,920,281 | 279.5 kb | Distal (>10kb) Multiome | 376 | |
| chr2:74,958,221–74,959,258 | 240.8 kb | Distal (>10kb) Multiome | 1096 | |
| chr2:75,055,603–75,056,664 | 143.2 kb | Distal (>10kb) Multiome | 263 | |
| chr2:75,153,714–75,154,360 | 45.3 kb | Distal (>10kb) Multiome | 222 | |
| chr2:75,199,295–75,200,926 | 1.2 kb | Proximal (<10kb) Multiome | 391 |
Genomic view of the TACR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.