This gene encodes a mitochondrial protein that function as a translational activator of mitochondrially-encoded cytochrome c oxidase 1. Mutations in this gene are associated with Leigh syndrome.[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for TACO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TACO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TACO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:63,445,554–63,447,581 | 154.7 kb | Distal (>10kb) Multiome HiCAR | 896 | |
| chr17:63,476,359–63,478,095 | 123.6 kb | Distal (>10kb) Multiome | 520 | |
| chr17:63,478,783–63,479,370 | 121.8 kb | Distal (>10kb) Multiome | 419 | |
| chr17:63,522,589–63,523,803 | 77.7 kb | Distal (>10kb) Multiome | 705 | |
| chr17:63,549,660–63,551,443 | 50.6 kb | Distal (>10kb) Multiome | 1037 | |
| chr17:63,600,715–63,601,423 | 12 bp | At TSS Multiome | 1122 | |
| chr17:63,621,512–63,623,359 | 21.1 kb | Distal (>10kb) Multiome | 956 | |
| chr17:63,698,705–63,701,428 | 99.3 kb | Distal (>10kb) Multiome | 663 | |
| chr17:63,741,119–63,742,935 | 141.0 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:63,773,179–63,774,727 | 172.9 kb | Distal (>10kb) Multiome | 1169 | |
| chr17:63,826,794–63,828,024 | 226.5 kb | Distal (>10kb) Multiome | 1008 | |
| chr17:63,841,547–63,843,442 | 242.1 kb | Distal (>10kb) Multiome | 1203 | |
| chr17:63,848,836–63,849,566 | 248.3 kb | Distal (>10kb) Multiome | 658 |
Genomic view of the TACO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.