TAC4

tachykinin precursor 4 | HK-1, PPT-C, Pptc

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Biological processes 18 terms

detection of temperature stimulus involved in sensory perception of pain (GO:0050965)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)inflammatory response (GO:0006954)negative regulation of sensory perception of pain (GO:1904057)negative regulation of systemic arterial blood pressure (GO:0003085)positive regulation of cytosolic calcium ion concentration (GO:0007204)positive regulation of cytosolic calcium ion concentration (GO:0007204)positive regulation of flagellated sperm motility (GO:1902093)positive regulation of sensory perception of pain (GO:1904058)receptor ligand activity (GO:0048018)regulation of sensory perception of pain (GO:0051930)substance K receptor binding (GO:0031837)substance P receptor binding (GO:0031835)substance P receptor binding (GO:0031835)tachykinin receptor signaling pathway (GO:0007217)tachykinin receptor signaling pathway (GO:0007217)

Expression (TPM)

TFs regulating TAC4 0 TFs

Transcription factors with Perturb-seq knockdown data for TAC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TAC4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:49,556,195–49,556,772	291.6 kb	Distal (>10kb) Multiome	636
chr17:49,567,907–49,568,549	279.9 kb	Distal (>10kb) Multiome	623
chr17:49,569,780–49,570,501	277.9 kb	Distal (>10kb) Multiome	893
chr17:49,575,427–49,577,397	272.3 kb	Distal (>10kb) Multiome	657
chr17:49,677,242–49,678,492	170.0 kb	Distal (>10kb) Multiome	1110
chr17:49,707,638–49,708,519	139.8 kb	Distal (>10kb) Multiome	927
chr17:49,763,285–49,764,743	83.8 kb	Distal (>10kb) Multiome	768
chr17:49,788,330–49,789,442	58.9 kb	Distal (>10kb) Multiome	1068
chr17:49,847,090–49,847,390	678 bp	At TSS	25
chr17:49,851,098–49,852,060	3.8 kb	Proximal (<10kb) Multiome	614
chr17:49,865,367–49,866,210	17.7 kb	Distal (>10kb) Multiome	213
chr17:49,880,287–49,880,820	32.6 kb	Distal (>10kb) Multiome	493
chr17:49,910,218–49,910,854	62.6 kb	Distal (>10kb) Multiome	230
chr17:49,968,328–49,969,629	121.0 kb	Distal (>10kb) Multiome	702
chr17:49,993,266–49,993,947	145.5 kb	Distal (>10kb) Multiome	222
chr17:49,994,638–49,995,383	147.1 kb	Distal (>10kb) Multiome	281
chr17:50,055,522–50,057,280	208.7 kb	Distal (>10kb) Multiome	654
chr17:50,094,331–50,095,951	247.2 kb	Distal (>10kb) Multiome	899
chr17:50,117,038–50,117,876	269.4 kb	Distal (>10kb) Multiome	488

Genome Browser

Genomic view of the TAC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.