The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for SYTL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYTL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYTL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:85,627,372–85,629,061 | 182.7 kb | Distal (>10kb) Multiome | 826 | |
| chr11:85,647,447–85,648,443 | 163.2 kb | Distal (>10kb) Multiome | 808 | |
| chr11:85,663,762–85,665,466 | 146.1 kb | Distal (>10kb) Multiome | 999 | |
| chr11:85,809,696–85,811,885 | 42 bp | At TSS Multiome | 535 | |
| chr11:85,854,605–85,855,812 | 43.9 kb | Distal (>10kb) Multiome | 948 | |
| chr11:86,068,044–86,070,093 | 258.1 kb | Distal (>10kb) Multiome | 1026 |
Genomic view of the SYTL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.