This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for SYT12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYT12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYT12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:66,728,259–66,728,943 | 278.3 kb | Distal (>10kb) Multiome | 275 | |
| chr11:66,744,354–66,745,291 | 262.0 kb | Distal (>10kb) Multiome | 747 | |
| chr11:66,842,896–66,843,952 | 163.4 kb | Distal (>10kb) Multiome | 843 | |
| chr11:66,855,758–66,857,980 | 150.4 kb | Distal (>10kb) Multiome | 795 | |
| chr11:66,957,708–66,959,038 | 48.2 kb | Distal (>10kb) Multiome | 957 | |
| chr11:67,023,002–67,023,688 | 16.6 kb | Distal (>10kb) Multiome | 243 | |
| chr11:67,056,596–67,057,312 | 50.1 kb | Distal (>10kb) Multiome | 382 | |
| chr11:67,071,470–67,071,999 | 65.0 kb | Distal (>10kb) Multiome | 302 | |
| chr11:67,117,553–67,120,314 | 112.3 kb | Distal (>10kb) Multiome | 762 | |
| chr11:67,239,493–67,240,241 | 233.1 kb | Distal (>10kb) Multiome | 792 | |
| chr11:67,265,898–67,267,077 | 259.7 kb | Distal (>10kb) Multiome | 471 | |
| chr11:67,288,260–67,289,971 | 282.4 kb | Distal (>10kb) Multiome | 985 | |
| chr11:67,302,488–67,304,170 | 296.6 kb | Distal (>10kb) Multiome | 661 |
Genomic view of the SYT12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.