SYCE2
synaptonemal complex central element protein 2 | CESC1

The protein encoded by this gene is part of the synaptonemal complex formed between homologous chromosomes during meiotic prophase. The encoded protein associates with SYCP1 and SYCE1 and is found only where chromosome cores are synapsed. [provided by RefSeq, Dec 2012]

Biological processes 15 terms
central element (GO:0000801)central element (GO:0000801)central element (GO:0000801)chromosome (GO:0005694)chromosome (GO:0005694)condensed nuclear chromosome (GO:0000794)homologous chromosome pairing at meiosis (GO:0007129)homologous recombination (GO:0035825)nucleoplasm (GO:0005654)nucleus (GO:0005634)protein binding (GO:0005515)reciprocal meiotic recombination (GO:0007131)synaptonemal complex (GO:0000795)synaptonemal complex assembly (GO:0007130)synaptonemal complex assembly (GO:0007130)
Expression (TPM)
SYCE2 — as a Regulated Gene

TFs regulating SYCE2 0 TFs

Transcription factors with Perturb-seq knockdown data for SYCE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYCE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SYCE2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYCE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:12,639,899–12,640,614 279.0 kb Distal (>10kb) Multiome 454
chr19:12,647,538–12,648,022 271.5 kb Distal (>10kb) Multiome 126
chr19:12,656,871–12,657,566 262.1 kb Distal (>10kb) Multiome 254
chr19:12,666,317–12,667,225 252.5 kb Distal (>10kb) Multiome 495
chr19:12,669,351–12,669,939 249.7 kb Distal (>10kb) Multiome 777
chr19:12,681,003–12,682,117 237.9 kb Distal (>10kb) Multiome 994
chr19:12,696,035–12,696,970 222.7 kb Distal (>10kb) Multiome 806
chr19:12,702,968–12,703,602 216.1 kb Distal (>10kb) Multiome 121
chr19:12,721,692–12,723,084 196.8 kb Distal (>10kb) Multiome 807
chr19:12,723,726–12,724,142 195.2 kb Distal (>10kb) Multiome 539
chr19:12,734,221–12,735,284 184.6 kb Distal (>10kb) Multiome 882
chr19:12,736,470–12,737,780 182.1 kb Distal (>10kb) Multiome 742
chr19:12,757,454–12,758,297 161.5 kb Distal (>10kb) Multiome 588
chr19:12,765,876–12,766,545 153.0 kb Distal (>10kb) Multiome 557
chr19:12,774,659–12,776,025 143.9 kb Distal (>10kb) Multiome 803
chr19:12,777,481–12,778,589 141.4 kb Distal (>10kb) Multiome 661
chr19:12,782,418–12,783,038 136.6 kb Distal (>10kb) Multiome 699
chr19:12,789,543–12,790,654 129.3 kb Distal (>10kb) Multiome 717
chr19:12,790,960–12,793,231 127.8 kb Distal (>10kb) Multiome 1015
chr19:12,793,340–12,794,240 125.6 kb Distal (>10kb) Multiome 808
chr19:12,801,120–12,802,290 117.4 kb Distal (>10kb) Multiome 901
chr19:12,806,212–12,806,984 112.7 kb Distal (>10kb) Multiome 827
chr19:12,825,565–12,826,186 93.5 kb Distal (>10kb) Multiome 436
chr19:12,832,484–12,833,101 86.7 kb Distal (>10kb) Multiome 970
chr19:12,833,638–12,834,477 85.4 kb Distal (>10kb) Multiome 310
chr19:12,838,114–12,838,869 80.8 kb Distal (>10kb) Multiome 377
chr19:12,840,071–12,841,485 78.4 kb Distal (>10kb) Multiome 391
chr19:12,847,633–12,848,090 71.5 kb Distal (>10kb) Multiome 535
chr19:12,867,327–12,868,022 51.6 kb Distal (>10kb) Multiome 315
chr19:12,872,968–12,873,990 45.9 kb Distal (>10kb) Multiome 263
chr19:12,880,834–12,881,875 37.8 kb Distal (>10kb) Multiome 656
chr19:12,884,836–12,886,381 33.9 kb Distal (>10kb) Multiome 717
chr19:12,890,614–12,891,603 28.3 kb Distal (>10kb) Multiome 841
chr19:12,913,054–12,913,584 6.0 kb Proximal (<10kb) Multiome 373
chr19:12,919,018–12,919,719 92 bp At TSS Multiome 732
chr19:12,933,441–12,934,086 14.5 kb Distal (>10kb) Multiome 789
chr19:12,937,426–12,939,166 19.1 kb Distal (>10kb) Multiome 943
chr19:12,945,275–12,946,647 26.6 kb Distal (>10kb) Multiome 1015
chr19:12,956,801–12,957,360 37.9 kb Distal (>10kb) Multiome 747
chr19:12,964,998–12,965,862 46.1 kb Distal (>10kb) Multiome 733
chr19:12,983,506–12,983,997 64.4 kb Distal (>10kb) Multiome 688
chr19:13,051,485–13,052,169 132.5 kb Distal (>10kb) Multiome 649
chr19:13,061,195–13,061,672 142.2 kb Distal (>10kb) Multiome 544
chr19:13,069,469–13,070,306 150.5 kb Distal (>10kb) Multiome 334
chr19:13,093,620–13,094,260 174.6 kb Distal (>10kb) Multiome 411
chr19:13,095,079–13,096,870 176.2 kb Distal (>10kb) Multiome 501
chr19:13,102,495–13,103,074 183.5 kb Distal (>10kb) Multiome 606
chr19:13,116,411–13,117,080 197.4 kb Distal (>10kb) Multiome 812
chr19:13,117,979–13,119,416 198.9 kb Distal (>10kb) Multiome 699
chr19:13,149,468–13,156,577 231.0 kb Distal (>10kb) Multiome 1333
chr19:13,162,579–13,165,523 245.5 kb Distal (>10kb) Multiome 1112
chr19:13,167,359–13,168,023 248.4 kb Distal (>10kb) Multiome 764

Genome Browser

Genomic view of the SYCE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:12,629,899 – 13,178,023
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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