Predicted to be involved in synaptonemal complex assembly. Located in intermediate filament cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SYCE1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYCE1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYCE1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:75,463,598–75,465,197 | 1747.7 kb | Distal (>10kb) Multiome HiCAR | 999 | |
| chr16:75,516,521–75,518,019 | 1695.0 kb | Distal (>10kb) Multiome HiCAR | 921 | |
| chr16:75,565,779–75,567,123 | 1646.1 kb | Distal (>10kb) Multiome HiCAR | 834 | |
| chr16:75,622,804–75,623,690 | 1589.1 kb | Distal (>10kb) Multiome HiCAR | 852 | |
| chr16:75,647,337–75,649,003 | 1564.7 kb | Distal (>10kb) Multiome HiCAR | 1002 | |
| chr16:77,133,565–77,134,646 | 78.4 kb | Distal (>10kb) Multiome | 131 | |
| chr16:77,190,160–77,191,630 | 21.6 kb | Distal (>10kb) Multiome | 915 | |
| chr16:77,211,464–77,213,653 | 42 bp | At TSS Multiome | 644 | |
| chr16:77,236,023–77,236,607 | 23.8 kb | Distal (>10kb) Multiome | 599 | |
| chr16:77,271,511–77,272,289 | 59.4 kb | Distal (>10kb) Multiome | 111 | |
| chr16:77,372,736–77,373,414 | 160.6 kb | Distal (>10kb) Multiome | 34 | |
| chr16:77,434,220–77,435,703 | 222.6 kb | Distal (>10kb) Multiome | 315 | |
| chr16:77,438,635–77,439,833 | 226.9 kb | Distal (>10kb) Multiome | 183 | |
| chr16:77,467,613–77,468,318 | 255.6 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the SYCE1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.