Involved in several processes, including TORC2 signaling; cellular response to epidermal growth factor stimulus; and cellular response to peptide hormone stimulus. Located in several cellular components, including Golgi apparatus; cytoplasmic side of plasma membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SYAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SYAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SYAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:16,712,105–16,712,490 | 7.1 kb | Proximal (<10kb) | 387 | |
| chrX:16,712,602–16,712,792 | 6.8 kb | Proximal (<10kb) | 456 | |
| chrX:16,719,154–16,719,979 | 52 bp | At TSS Multiome | 716 | |
| chrX:16,771,090–16,772,164 | 52.1 kb | Distal (>10kb) Multiome | 626 | |
| chrX:16,786,080–16,787,269 | 66.7 kb | Distal (>10kb) Multiome | 646 | |
| chrX:16,869,468–16,871,503 | 150.9 kb | Distal (>10kb) Multiome | 687 | |
| chrX:16,946,195–16,947,346 | 227.0 kb | Distal (>10kb) Multiome | 329 | |
| chrX:17,007,183–17,007,806 | 287.8 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the SYAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.