The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for SVOPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SVOPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SVOPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:138,001,408–138,002,587 | 625.2 kb | Distal (>10kb) Multiome HiCAR | 897 | |
| chr7:138,458,615–138,459,181 | 168.6 kb | Distal (>10kb) Multiome | 126 | |
| chr7:138,459,619–138,461,506 | 167.3 kb | Distal (>10kb) Multiome | 1036 | |
| chr7:138,663,702–138,664,161 | 550 bp | At TSS | 166 | |
| chr7:138,668,180–138,668,461 | 5.0 kb | Proximal (<10kb) | 33 | |
| chr7:138,773,729–138,774,234 | 146.6 kb | Distal (>10kb) Multiome | 243 | |
| chr7:138,797,807–138,798,337 | 170.7 kb | Distal (>10kb) Multiome | 145 |
Genomic view of the SVOPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.