Predicted to enable hyaluronic acid binding activity. Predicted to be involved in Notch signaling pathway. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SUSD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUSD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUSD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:33,096,220–33,097,726 | 121.6 kb | Distal (>10kb) Multiome | 905 | |
| chr3:33,113,579–33,114,881 | 104.4 kb | Distal (>10kb) Multiome | 870 | |
| chr3:33,218,068–33,219,328 | 43 bp | At TSS Multiome | 329 | |
| chr3:33,277,037–33,277,887 | 58.6 kb | Distal (>10kb) Multiome | 534 | |
| chr3:33,425,913–33,426,646 | 207.5 kb | Distal (>10kb) Multiome | 224 | |
| chr3:33,439,404–33,441,603 | 221.8 kb | Distal (>10kb) Multiome | 1014 | |
| chr3:33,446,268–33,447,578 | 227.7 kb | Distal (>10kb) Multiome | 160 |
Genomic view of the SUSD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.