This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SURF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SURF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SURF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:133,059,688–133,060,833 | 296.0 kb | Distal (>10kb) Multiome | 222 | |
| chr9:133,120,589–133,121,652 | 235.2 kb | Distal (>10kb) Multiome | 599 | |
| chr9:133,144,161–133,144,920 | 211.9 kb | Distal (>10kb) Multiome | 776 | |
| chr9:133,147,412–133,149,938 | 207.1 kb | Distal (>10kb) Multiome | 979 | |
| chr9:133,163,575–133,164,128 | 192.6 kb | Distal (>10kb) Multiome HiCAR | 308 | |
| chr9:133,238,117–133,239,420 | 117.8 kb | Distal (>10kb) Multiome | 620 | |
| chr9:133,335,737–133,336,702 | 20.2 kb | Distal (>10kb) Multiome | 1038 | |
| chr9:133,347,434–133,348,830 | 8.3 kb | Proximal (<10kb) Multiome | 893 | |
| chr9:133,351,969–133,352,293 | 4.2 kb | Proximal (<10kb) | 435 | |
| chr9:133,356,029–133,357,223 | 86 bp | At TSS Multiome | 648 | |
| chr9:133,375,394–133,376,740 | 19.7 kb | Distal (>10kb) Multiome | 834 | |
| chr9:133,417,747–133,418,516 | 61.6 kb | Distal (>10kb) Multiome | 1015 | |
| chr9:133,428,444–133,429,113 | 72.2 kb | Distal (>10kb) Multiome | 255 | |
| chr9:133,429,621–133,430,196 | 73.4 kb | Distal (>10kb) Multiome | 197 | |
| chr9:133,458,883–133,460,984 | 103.4 kb | Distal (>10kb) Multiome | 835 | |
| chr9:133,478,485–133,479,696 | 122.7 kb | Distal (>10kb) Multiome | 653 | |
| chr9:133,534,455–133,535,168 | 178.2 kb | Distal (>10kb) Multiome | 295 | |
| chr9:133,608,924–133,609,730 | 252.9 kb | Distal (>10kb) Multiome | 411 |
Genomic view of the SURF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.