SUPV3L1

Suv3 like RNA helicase | SUV3

Enables several functions, including double-stranded RNA binding activity; helicase activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA 3'-end processing; mitochondrial RNA surveillance; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrial nucleoid and nucleus. Part of mitochondrial degradosome. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 45 terms

3'-5' RNA helicase activity (GO:0034458)3'-5' RNA helicase activity (GO:0034458)3'-5'-RNA exonuclease activity (GO:0000175)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)DNA binding (GO:0003677)DNA helicase activity (GO:0003678)DNA recombination (GO:0006310)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA catabolic process (GO:0006401)RNA helicase activity (GO:0003724)RNA helicase activity (GO:0003724)double-stranded RNA binding (GO:0003725)helicase activity (GO:0004386)identical protein binding (GO:0042802)mitochondrial RNA 3'-end processing (GO:0000965)mitochondrial RNA 3'-end processing (GO:0000965)mitochondrial RNA catabolic process (GO:0000957)mitochondrial RNA catabolic process (GO:0000957)mitochondrial RNA surveillance (GO:2000827)mitochondrial degradosome (GO:0045025)mitochondrial degradosome (GO:0045025)mitochondrial mRNA catabolic process (GO:0000958)mitochondrial mRNA surveillance (GO:0035946)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial ncRNA surveillance (GO:0035945)mitochondrial nucleoid (GO:0042645)mitochondrial nucleoid (GO:0042645)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion organization (GO:0007005)negative regulation of apoptotic process (GO:0043066)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of cell growth (GO:0030307)positive regulation of mitochondrial RNA catabolic process (GO:0000962)positive regulation of mitochondrial RNA catabolic process (GO:0000962)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)

Expression (TPM)

TFs regulating SUPV3L1 0 TFs

Transcription factors with Perturb-seq knockdown data for SUPV3L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUPV3L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SUPV3L1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUPV3L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:68,900,541–68,901,785	279.1 kb	Distal (>10kb) Multiome	1082
chr10:68,955,769–68,956,761	224.1 kb	Distal (>10kb) Multiome	938
chr10:68,988,361–68,989,558	191.4 kb	Distal (>10kb) Multiome	896
chr10:69,123,352–69,125,173	56.2 kb	Distal (>10kb) Multiome	918
chr10:69,179,817–69,180,725	121 bp	At TSS Multiome	900
chr10:69,317,873–69,319,610	138.4 kb	Distal (>10kb) Multiome	675
chr10:69,329,639–69,330,213	149.7 kb	Distal (>10kb) Multiome	155
chr10:69,375,626–69,376,241	195.7 kb	Distal (>10kb) Multiome	178
chr10:69,392,338–69,392,832	212.4 kb	Distal (>10kb) Multiome	454
chr10:69,408,469–69,409,338	228.6 kb	Distal (>10kb) Multiome	705
chr10:69,449,843–69,450,266	269.7 kb	Distal (>10kb) Multiome	301
chr10:69,450,797–69,452,284	271.2 kb	Distal (>10kb) Multiome	508

Genome Browser

Genomic view of the SUPV3L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.