This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for SUMO3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SUMO3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SUMO3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:44,686,253–44,687,168 | 131.4 kb | Distal (>10kb) Multiome | 199 | |
| chr21:44,711,499–44,711,908 | 106.3 kb | Distal (>10kb) Multiome | 168 | |
| chr21:44,748,550–44,748,985 | 69.2 kb | Distal (>10kb) Multiome | 149 | |
| chr21:44,801,527–44,802,290 | 16.2 kb | Distal (>10kb) Multiome | 818 | |
| chr21:44,817,098–44,818,998 | 165 bp | At TSS Multiome | 775 | |
| chr21:44,845,753–44,846,245 | 27.9 kb | Distal (>10kb) Multiome | 504 | |
| chr21:44,872,991–44,875,251 | 55.7 kb | Distal (>10kb) Multiome | 841 | |
| chr21:44,939,797–44,940,292 | 121.9 kb | Distal (>10kb) Multiome | 1041 | |
| chr21:45,073,773–45,075,747 | 256.4 kb | Distal (>10kb) Multiome | 883 |
Genomic view of the SUMO3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.