This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SULT4A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SULT4A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SULT4A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:43,216,557–43,217,579 | 645.5 kb | Distal (>10kb) Multiome HiCAR | 90 | |
| chr22:43,231,079–43,231,533 | 631.1 kb | Distal (>10kb) Multiome HiCAR | 240 | |
| chr22:43,812,012–43,812,763 | 50.2 kb | Distal (>10kb) Multiome | 493 | |
| chr22:43,861,938–43,862,881 | 25 bp | At TSS Multiome | 263 | |
| chr22:43,891,548–43,892,393 | 29.5 kb | Distal (>10kb) Multiome | 185 | |
| chr22:43,923,130–43,924,772 | 61.3 kb | Distal (>10kb) Multiome | 741 | |
| chr22:43,925,117–43,926,046 | 63.1 kb | Distal (>10kb) Multiome | 441 | |
| chr22:43,955,027–43,955,843 | 92.9 kb | Distal (>10kb) Multiome | 809 | |
| chr22:44,023,900–44,024,505 | 161.7 kb | Distal (>10kb) Multiome | 355 | |
| chr22:44,046,421–44,047,108 | 184.4 kb | Distal (>10kb) Multiome | 200 | |
| chr22:44,147,624–44,148,539 | 285.6 kb | Distal (>10kb) Multiome | 144 | |
| chr22:44,661,031–44,661,516 | 798.7 kb | Distal (>10kb) Multiome HiCAR | 28 | |
| chr22:44,668,163–44,669,181 | 806.0 kb | Distal (>10kb) Multiome HiCAR | 265 |
Genomic view of the SULT4A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.