Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for SULT1A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SULT1A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SULT1A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,899,174–29,900,833 | 300.4 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 273.6 kb | Distal (>10kb) Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 237.9 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 226.2 kb | Distal (>10kb) Multiome | 935 | |
| chr16:29,994,888–29,996,728 | 204.6 kb | Distal (>10kb) Multiome | 1080 | |
| chr16:30,021,215–30,021,860 | 178.3 kb | Distal (>10kb) Multiome | 764 | |
| chr16:30,052,803–30,053,364 | 146.8 kb | Distal (>10kb) Multiome | 989 | |
| chr16:30,063,722–30,066,296 | 134.3 kb | Distal (>10kb) Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 123.9 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 107.9 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 103.5 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,122,728–30,123,578 | 76.7 kb | Distal (>10kb) Multiome | 718 | |
| chr16:30,182,759–30,183,865 | 16.4 kb | Distal (>10kb) Multiome | 547 | |
| chr16:30,334,526–30,335,777 | 135.5 kb | Distal (>10kb) Multiome | 486 | |
| chr16:30,354,854–30,355,978 | 155.6 kb | Distal (>10kb) Multiome | 1070 | |
| chr16:30,369,220–30,371,611 | 170.9 kb | Distal (>10kb) Multiome | 818 | |
| chr16:30,377,495–30,379,532 | 178.5 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,394,422–30,396,098 | 195.4 kb | Distal (>10kb) Multiome | 941 | |
| chr16:30,400,026–30,401,048 | 200.7 kb | Distal (>10kb) Multiome | 839 | |
| chr16:30,406,974–30,408,429 | 207.6 kb | Distal (>10kb) Multiome | 908 | |
| chr16:30,417,414–30,418,576 | 218.2 kb | Distal (>10kb) Multiome | 543 | |
| chr16:30,429,571–30,430,773 | 230.4 kb | Distal (>10kb) Multiome | 1060 | |
| chr16:30,445,340–30,446,062 | 245.9 kb | Distal (>10kb) Multiome | 898 |
Genomic view of the SULT1A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.