Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for STYK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STYK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STYK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:10,211,987–10,214,332 | 461.4 kb | Distal (>10kb) Multiome HiCAR | 873 | |
| chr12:10,557,141–10,558,180 | 116.5 kb | Distal (>10kb) Multiome | 180 | |
| chr12:10,613,109–10,614,787 | 60.4 kb | Distal (>10kb) Multiome | 875 | |
| chr12:10,673,596–10,674,631 | 197 bp | At TSS Multiome | 554 | |
| chr12:10,721,993–10,723,742 | 49.3 kb | Distal (>10kb) Multiome | 885 |
Genomic view of the STYK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.