STXBP1

syntaxin binding protein 1 | MUNC18-1, UNC18, hUNC18, nSec1, rbSec1

This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Biological processes 63 terms

RNA binding (GO:0003723)SNARE binding (GO:0000149)SNARE binding (GO:0000149)SNARE complex assembly (GO:0035493)axon (GO:0030424)axon target recognition (GO:0007412)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)developmental process involved in reproduction (GO:0003006)establishment of localization in cell (GO:0051649)evoked neurotransmitter secretion (GO:0061670)extracellular exosome (GO:0070062)identical protein binding (GO:0042802)identical protein binding (GO:0042802)intracellular protein transport (GO:0006886)membrane (GO:0016020)mitochondrion (GO:0005739)negative regulation of protein-containing complex assembly (GO:0031333)negative regulation of synaptic transmission, GABAergic (GO:0032229)perinuclear region of cytoplasm (GO:0048471)phospholipase binding (GO:0043274)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)platelet aggregation (GO:0070527)platelet alpha granule (GO:0031091)platelet degranulation (GO:0002576)positive regulation of exocytosis (GO:0045921)positive regulation of glutamate secretion, neurotransmission (GO:1903296)positive regulation of mast cell degranulation (GO:0043306)positive regulation of synaptic vesicle priming (GO:0010808)positive regulation of vesicle docking (GO:0106022)positive regulation of vesicle fusion (GO:0031340)postsynapse (GO:0098794)presynapse (GO:0098793)presynaptic dense core vesicle exocytosis (GO:0099525)protein binding (GO:0005515)protein domain specific binding (GO:0019904)protein kinase binding (GO:0019901)protein localization to plasma membrane (GO:0072659)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)regulated exocytosis (GO:0045055)regulation of SNARE complex assembly (GO:0035542)regulation of acrosomal vesicle exocytosis (GO:2000367)regulation of regulated secretory pathway (GO:1903305)regulation of synaptic vesicle fusion to presynaptic active zone membrane (GO:0031630)regulation of synaptic vesicle priming (GO:0010807)regulation of synaptic vesicle priming (GO:0010807)regulation of vesicle fusion (GO:0031338)response to estradiol (GO:0032355)secretory granule (GO:0030141)secretory granule (GO:0030141)synaptic vesicle maturation (GO:0016188)syntaxin binding (GO:0019905)syntaxin-1 binding (GO:0017075)vesicle docking involved in exocytosis (GO:0006904)vesicle docking involved in exocytosis (GO:0006904)vesicle-mediated transport (GO:0016192)

Expression (TPM)

TFs regulating STXBP1 0 TFs

Transcription factors with Perturb-seq knockdown data for STXBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STXBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to STXBP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STXBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr9:127,396,281–127,398,388	215.3 kb	Distal (>10kb) Multiome	843
chr9:127,423,809–127,424,734	188.0 kb	Distal (>10kb) Multiome	791
chr9:127,450,607–127,452,473	160.9 kb	Distal (>10kb) Multiome	1009
chr9:127,567,936–127,569,972	43.1 kb	Distal (>10kb) Multiome	660
chr9:127,608,129–127,608,913	3.7 kb	Proximal (<10kb) Multiome	700
chr9:127,611,734–127,612,761	81 bp	At TSS Multiome	566
chr9:127,613,060–127,613,424	791 bp	At TSS	324
chr9:127,699,155–127,699,632	87.2 kb	Distal (>10kb) Multiome	440
chr9:127,715,013–127,716,345	103.5 kb	Distal (>10kb) Multiome HiCAR	735
chr9:127,734,444–127,735,606	123.0 kb	Distal (>10kb) Multiome	836
chr9:127,741,739–127,743,092	130.6 kb	Distal (>10kb) Multiome	367
chr9:127,754,123–127,755,506	143.1 kb	Distal (>10kb) Multiome	279
chr9:127,770,807–127,771,925	159.2 kb	Distal (>10kb) Multiome	550
chr9:127,784,682–127,787,009	174.3 kb	Distal (>10kb) Multiome	858
chr9:127,802,385–127,803,632	190.7 kb	Distal (>10kb) Multiome	867
chr9:127,809,338–127,810,272	197.6 kb	Distal (>10kb) Multiome	276
chr9:127,825,222–127,826,046	213.4 kb	Distal (>10kb) Multiome	451
chr9:127,828,234–127,829,024	216.3 kb	Distal (>10kb) Multiome	521
chr9:127,877,282–127,878,202	265.5 kb	Distal (>10kb) Multiome	531
chr9:127,897,316–127,897,796	285.2 kb	Distal (>10kb) Multiome	437
chr9:127,898,861–127,900,094	287.3 kb	Distal (>10kb) Multiome	630

Genome Browser

Genomic view of the STXBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.