Transcription factors with Perturb-seq knockdown data for STX18-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STX18-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STX18-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:4,247,950–4,248,717 | 293.9 kb | Distal (>10kb) Multiome | 853 | |
| chr4:4,289,645–4,290,743 | 251.9 kb | Distal (>10kb) Multiome | 779 | |
| chr4:4,386,227–4,387,401 | 155.6 kb | Distal (>10kb) Multiome | 247 | |
| chr4:4,541,695–4,542,519 | 76 bp | At TSS Multiome | 1129 | |
| chr4:4,574,736–4,575,902 | 33.3 kb | Distal (>10kb) Multiome | 433 | |
| chr4:4,641,708–4,642,896 | 100.3 kb | Distal (>10kb) Multiome | 338 | |
| chr4:4,667,130–4,668,212 | 125.6 kb | Distal (>10kb) Multiome | 171 | |
| chr4:4,673,012–4,673,515 | 131.1 kb | Distal (>10kb) Multiome | 164 | |
| chr4:4,763,386–4,764,175 | 221.5 kb | Distal (>10kb) Multiome | 333 |
Genomic view of the STX18-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.