This gene belongs to the syntaxin family and encodes a soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE). The encoded protein is involved in docking and fusion events at the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for STX10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STX10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STX10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:12,867,327–12,868,022 | 282.7 kb | Distal (>10kb) Multiome | 315 | |
| chr19:12,872,968–12,873,990 | 277.0 kb | Distal (>10kb) Multiome | 263 | |
| chr19:12,880,834–12,881,875 | 268.9 kb | Distal (>10kb) Multiome | 656 | |
| chr19:12,884,836–12,886,381 | 265.0 kb | Distal (>10kb) Multiome | 717 | |
| chr19:12,890,614–12,891,603 | 259.4 kb | Distal (>10kb) Multiome | 841 | |
| chr19:12,913,054–12,913,584 | 237.0 kb | Distal (>10kb) Multiome | 373 | |
| chr19:12,919,018–12,919,719 | 231.0 kb | Distal (>10kb) Multiome | 732 | |
| chr19:12,933,441–12,934,086 | 216.6 kb | Distal (>10kb) Multiome | 789 | |
| chr19:12,937,426–12,939,166 | 211.9 kb | Distal (>10kb) Multiome | 943 | |
| chr19:12,945,275–12,946,647 | 204.4 kb | Distal (>10kb) Multiome | 1015 | |
| chr19:12,956,801–12,957,360 | 193.1 kb | Distal (>10kb) Multiome | 747 | |
| chr19:12,964,998–12,965,862 | 185.0 kb | Distal (>10kb) Multiome | 733 | |
| chr19:12,983,506–12,983,997 | 166.7 kb | Distal (>10kb) Multiome | 688 | |
| chr19:13,051,485–13,052,169 | 98.5 kb | Distal (>10kb) Multiome | 649 | |
| chr19:13,061,195–13,061,672 | 88.9 kb | Distal (>10kb) Multiome | 544 | |
| chr19:13,069,469–13,070,306 | 80.6 kb | Distal (>10kb) Multiome | 334 | |
| chr19:13,093,620–13,094,260 | 56.5 kb | Distal (>10kb) Multiome | 411 | |
| chr19:13,095,079–13,096,870 | 54.9 kb | Distal (>10kb) Multiome | 501 | |
| chr19:13,102,495–13,103,074 | 47.5 kb | Distal (>10kb) Multiome | 606 | |
| chr19:13,116,411–13,117,080 | 33.7 kb | Distal (>10kb) Multiome | 812 | |
| chr19:13,117,979–13,119,416 | 32.2 kb | Distal (>10kb) Multiome | 699 | |
| chr19:13,149,468–13,156,577 | 76 bp | At TSS Multiome | 1333 | |
| chr19:13,162,579–13,165,523 | 14.4 kb | Distal (>10kb) Multiome | 1112 | |
| chr19:13,167,359–13,168,023 | 17.3 kb | Distal (>10kb) Multiome | 764 | |
| chr19:13,841,592–13,843,282 | 692.5 kb | Distal (>10kb) Multiome HiCAR | 600 | |
| chr19:13,846,368–13,848,126 | 697.3 kb | Distal (>10kb) Multiome HiCAR | 1040 |
Genomic view of the STX10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.