Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STUM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STUM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STUM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:226,308,507–226,309,932 | 239.5 kb | Distal (>10kb) Multiome | 915 | |
| chr1:226,404,588–226,405,519 | 143.6 kb | Distal (>10kb) Multiome | 185 | |
| chr1:226,407,433–226,408,738 | 140.6 kb | Distal (>10kb) Multiome | 894 | |
| chr1:226,547,741–226,548,063 | 699 bp | At TSS | 399 | |
| chr1:226,548,271–226,549,075 | 10 bp | At TSS Multiome | 269 | |
| chr1:226,549,731–226,550,720 | 968 bp | At TSS | 232 | |
| chr1:226,679,874–226,680,709 | 131.5 kb | Distal (>10kb) Multiome | 422 | |
| chr1:226,827,950–226,828,394 | 279.4 kb | Distal (>10kb) Multiome | 514 |
Genomic view of the STUM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.