Involved in cell migration; cytoskeleton organization; and regulation of cell shape. Located in cytosol. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STRIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STRIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STRIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:129,144,393–129,145,068 | 289.7 kb | Distal (>10kb) Multiome | 477 | |
| chr7:129,168,405–129,170,130 | 265.2 kb | Distal (>10kb) Multiome | 302 | |
| chr7:129,188,088–129,189,694 | 245.8 kb | Distal (>10kb) Multiome | 603 | |
| chr7:129,224,228–129,225,767 | 209.6 kb | Distal (>10kb) Multiome | 899 | |
| chr7:129,433,659–129,435,261 | 85 bp | At TSS Multiome | 770 | |
| chr7:129,453,732–129,454,848 | 19.9 kb | Distal (>10kb) Multiome | 197 | |
| chr7:129,502,098–129,503,287 | 68.0 kb | Distal (>10kb) Multiome | 480 | |
| chr7:129,611,327–129,612,516 | 177.3 kb | Distal (>10kb) Multiome | 882 |
Genomic view of the STRIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.