STOX1
storkhead box 1 | FLJ25162, C10orf24

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to nitrosative stress; positive regulation of mitotic cell cycle phase transition; and regulation of macromolecule metabolic process. Located in centrosome; cytosol; and nuclear lumen. Implicated in pre-eclampsia. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 38 terms
DNA-binding transcription factor activity (GO:0003700)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)cell cortex (GO:0005938)cellular response to nitrosative stress (GO:0071500)centrosome (GO:0005813)centrosome (GO:0005813)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)fibrillar center (GO:0001650)inner ear development (GO:0048839)negative regulation of gene expression (GO:0010629)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)positive regulation of cell cycle (GO:0045787)positive regulation of cyclin-dependent protein kinase activity (GO:1904031)positive regulation of gene expression (GO:0010628)positive regulation of otic vesicle morphogenesis (GO:1904120)positive regulation of peptidyl-serine phosphorylation (GO:0033138)positive regulation of peptidyl-threonine phosphorylation (GO:0010800)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)protein binding (GO:0005515)regulation of gene expression (GO:0010468)regulation of mitochondrial DNA metabolic process (GO:1901858)regulation of mitochondrial membrane potential (GO:0051881)regulation of mitochondrion organization (GO:0010821)regulation of mitotic cell cycle (GO:0007346)regulation of response to oxidative stress (GO:1902882)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)
Expression (TPM)
STOX1 — as a Regulated Gene

TFs regulating STOX1 0 TFs

Transcription factors with Perturb-seq knockdown data for STOX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STOX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to STOX1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STOX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr10:68,527,011–68,528,012 300.0 kb Distal (>10kb) Multiome 912
chr10:68,559,963–68,561,065 267.1 kb Distal (>10kb) Multiome 777
chr10:68,600,036–68,600,760 227.1 kb Distal (>10kb) Multiome 755
chr10:68,720,659–68,721,908 106.3 kb Distal (>10kb) Multiome 939
chr10:68,826,917–68,827,679 202 bp At TSS Multiome 577
chr10:68,828,242–68,828,650 712 bp At TSS 229
chr10:68,900,541–68,901,785 73.6 kb Distal (>10kb) Multiome 1082
chr10:68,955,769–68,956,761 128.6 kb Distal (>10kb) Multiome 938
chr10:68,988,361–68,989,558 161.3 kb Distal (>10kb) Multiome 896
chr10:69,123,352–69,125,173 296.6 kb Distal (>10kb) Multiome 918

Genome Browser

Genomic view of the STOX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr10:68,517,011 – 69,135,173
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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