Enables GTPase binding activity; T cell receptor binding activity; and cardiolipin binding activity. Involved in intracellular calcium ion homeostasis; mitochondrion organization; and protein complex oligomerization. Acts upstream of or within T cell receptor signaling pathway. Located in several cellular components, including immunological synapse; membrane raft; and mitochondrial envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for STOML2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STOML2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STOML2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,957,639–34,958,516 | 145.0 kb | Distal (>10kb) Multiome | 211 | |
| chr9:34,988,494–34,990,699 | 113.5 kb | Distal (>10kb) Multiome | 703 | |
| chr9:35,026,200–35,027,109 | 76.2 kb | Distal (>10kb) Multiome | 187 | |
| chr9:35,071,688–35,073,229 | 31.1 kb | Distal (>10kb) Multiome | 975 | |
| chr9:35,079,435–35,080,247 | 23.2 kb | Distal (>10kb) Multiome | 773 | |
| chr9:35,095,921–35,096,910 | 6.7 kb | Proximal (<10kb) Multiome | 960 | |
| chr9:35,102,684–35,103,800 | 123 bp | At TSS Multiome | 886 | |
| chr9:35,110,953–35,112,122 | 8.5 kb | Proximal (<10kb) Multiome | 527 | |
| chr9:35,113,899–35,117,460 | 14.2 kb | Distal (>10kb) Multiome | 840 | |
| chr9:35,161,521–35,162,743 | 58.9 kb | Distal (>10kb) Multiome | 827 | |
| chr9:35,406,111–35,407,050 | 303.5 kb | Distal (>10kb) Multiome HiCAR | 145 | |
| chr9:35,603,584–35,606,173 | 501.1 kb | Distal (>10kb) Multiome HiCAR | 918 |
Genomic view of the STOML2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.