This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for STK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:98,825,100–98,826,604 | 262 bp | At TSS Multiome | 692 | |
| chr8:98,939,766–98,942,896 | 115.5 kb | Distal (>10kb) Multiome | 801 | |
| chr8:98,944,134–98,945,767 | 118.7 kb | Distal (>10kb) Multiome | 736 | |
| chr8:98,947,167–98,948,851 | 122.2 kb | Distal (>10kb) Multiome | 160 | |
| chr8:98,951,052–98,951,938 | 125.8 kb | Distal (>10kb) Multiome | 211 | |
| chr8:98,972,223–98,972,842 | 146.7 kb | Distal (>10kb) Multiome | 201 | |
| chr8:98,973,362–98,974,798 | 148.7 kb | Distal (>10kb) Multiome | 321 | |
| chr8:99,012,513–99,013,978 | 187.5 kb | Distal (>10kb) Multiome | 985 |
Genomic view of the STK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.