This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for STK25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:241,217,134–241,217,954 | 290.9 kb | Distal (>10kb) Multiome | 700 | |
| chr2:241,272,147–241,273,188 | 235.8 kb | Distal (>10kb) Multiome | 539 | |
| chr2:241,314,756–241,316,790 | 193.1 kb | Distal (>10kb) Multiome | 1143 | |
| chr2:241,354,545–241,355,644 | 153.6 kb | Distal (>10kb) Multiome | 625 | |
| chr2:241,355,946–241,356,875 | 152.4 kb | Distal (>10kb) Multiome | 680 | |
| chr2:241,507,257–241,509,444 | 113 bp | At TSS Multiome | 1050 | |
| chr2:241,540,846–241,542,485 | 32.7 kb | Distal (>10kb) Multiome | 394 | |
| chr2:241,558,542–241,559,899 | 50.2 kb | Distal (>10kb) Multiome | 638 | |
| chr2:241,609,833–241,610,860 | 101.8 kb | Distal (>10kb) Multiome | 755 | |
| chr2:241,636,378–241,638,145 | 128.8 kb | Distal (>10kb) Multiome | 934 | |
| chr2:241,686,350–241,687,468 | 178.3 kb | Distal (>10kb) Multiome | 895 | |
| chr2:241,701,038–241,703,402 | 192.8 kb | Distal (>10kb) Multiome | 1081 | |
| chr2:241,734,032–241,735,695 | 226.0 kb | Distal (>10kb) Multiome | 977 |
Genomic view of the STK25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.